A Guide for Estimating the Maximum Safe Starting Dose and Conversion it between Animals and Humans

With the development of drugs and the emergence of new drugs, new experiences in animals or clinical trials in humans are important in understanding the translation of the drug dose between different species, as well as converting the dose from animal studies to human or vice versa based on the differences in the average body weight (kg) of species to its body surface area (m2) according Allometric approach during extrapolation doses of starting therapeutic agents among the species. this article have provided basic information about estimating the starting dose for clinical trials, especially for phase I and phase II, or about the translation of doses between species using the allometric scaling also, based on human equivalent dose we provided method for calculation of injection volume of parenteral formulation.