Synergistic Antitumor Efficacy Of Radium-223 And Enzalutamide In The Intratibial Lncap Prostate Cancer Xenograft Model.

Mari I Suominen,Matias Knuuttila,Jukka Vääräniemi,Birgitta Sjöholm,Esa Alhoniemi,Dominik Mumberg,Sanna-Maria Käkönen,Arne Scholz

JOURNAL OF CLINICAL ONCOLOGY（2021）

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摘要

105Background: Radium-223 dichloride (Ra-223) is a targeted alpha therapy that binds to newly formed bone matrix in bone metastases and induces DNA double-strand breaks in cancer cells, osteoblasts...

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