DNA interactions, antitubercular and cytotoxic activity of heteroleptic CuII complexes containing 1,10-phenanthroline

Janaína do Couto Almeida, Raphael T.C. Silva,Renan D. Zanetti,Mariete B. Moreira,Marcelo C. Portes,Lorena Polloni, Fernanda V.P. de Vasconcelos Azevedo,Gustavo Von Poelhsitz,Marcos Pivatto,Adelino V.G. Netto, Veridiana de Melo R. Ávila, Karyn F. Manieri,Fernando R. Pavan,Ana M. Da Costa Ferreira,Wendell Guerra

Journal of Molecular Structure（2021）

引用 4|浏览6

暂无评分

摘要

•Four heteroleptic CuII complexes with 1,10-phenanthroline were prepared.•Such complexes were more cytotoxic than corresponding free ligands and carboplatin.•These complexes efficiently bind to ct-DNA with kb values in the range of 103 M‒1.•Additionally, these CuII complexes exhibited potent antimycobacterial activity.

查看译文

关键词

Copper(II) complexes,Cytotoxic activity,Mycobacterium tuberculosis, DNA binding studies, Spectroscopic methods

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要