Outcomes And Toxicities Of Re-Irradiation For Prostate Cancer: A Systematic Review On Behalf Of The Re-Irradiation Working Group Of The Italian Association Of Radiotherapy And Clinical Oncology (Airo)

Aims: The best therapeutic approach for local relapses of previously irradiated prostate cancer (PC) is still not defined. Re-irradiation (Re-I) could offer a chance of cure for highly selected patients, although high quality evidences are lacking. The aim of our study is to provide a literature review on efficacy and safety of Re-I. Methods: Only studies where Re-I field overlaps with previous radiotherapy were considered. To determine 2 and 4 years overall mortality (OM), 2 and 4 years biochemical failure (BF) and pooled acute and late G 0.001). The pooled result of G 0.001). One hundred and three G 3 late adverse events were reported, with a pooled result of G > 3 late toxicity of 8.7% (95%CI: 5.8?13%, P < 0.001). Conclusions: Re-I of local failures from PC showed promising OM and biochemical control rates with a safe toxicity profile.