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Metal-Organic Nanostructure Based On Tixoy/Ruthenium Reaction Units: For Ct/Mr Imaging-Guided X-Ray Induced Dynamic Therapy

CHEMICAL ENGINEERING JOURNAL(2021)

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Abstract
We report a computed tomography/magnetic resonance (CT/MR) imaging-guided X-ray induced dynamic therapy (XDT) nanotheranostic platform based on TixOy/Ru reaction units. A new metal-organic nanostructure (TiZrRu-MON) was prepared via a solvothermal reaction of [Ti8Zr2O12(COO)(16)] clusters and bipyridine-(COOH)(2)/Ru(II)-bipyridine-(COOH)(2) co-organic ligands. We demonstrate that the cluster can absorb X-ray and transform the energy to Ru(II)-bipyridine-(COOH)(2) with effective reactive oxygen species (ROS) production, which is five times more than TiZr-MON. In addition, Gd(III) ions were anchored to the bipyridine of MON for concurrent CT/MR imaging. Notably, the TiZrRuGd-MON possesses ultrahigh longitudinal relaxivity (r(1) value up to 53.09 mM(-1).s(-1) at 1.5 T, 7-fold higher than commercial Gd-DTPA). With the guidance of CT/MR dual-mode imaging that provides comprehensive and complementary contrast information, the TiZrRuGd-MON is monitored to accumulate in tumor sites and eliminate tumor with high efficiency under X-ray irradiation. The TiZrRu-MON-based XDT strategy opens a pathway for clinical translational research of cancer theranostics.
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Key words
X-ray induced dynamic therapy, Metal-organic nanostructure, Magnetic resonance imaging, Computed tomography imaging
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