Synthesis of Dihydrochlorides of Azaadamantanes Containing 8-Hydroxyquinoline Fragments and their Antibacterial Activity in Mice with Dysentery and Staphylococcal Infections

New azaadamantane derivatives containing 8-hydroxyquinoline fragments were synthesized. Their antibacterial activity was studied. The synthesized compounds exhibited high antibacterial activity in vitro . The 6-oxo-5,7-diethyl- and 5,7-dimethyl-2-(8 ' -hydroxyquinolyl-5 ' )-1,3-diazaadamantane dihydrochlorides showed therapeutic effects in mice with dysentery and staphylococcal infections.