O058 / #560: SURVIVAL AND MORBIDITY ANALYSIS IN CHILDREN WITH CANCER IN THE ICU

Aims & Objectives: Some children with cancer in PICU will not return to their functional baseline at the end of hospitalization. We aimed to assess risk variables for changes in functional status. Methods: Retrospective cohort of patients admitted in PICU from January, 2014 to January, 2019. The FSS (Functional Status Scale) was applied at admission to the PICU and at hospital discharge, in survivors. A new morbidity was defined as an increase ≥ 3 points between admission and discharge. The outcome “new morbidity” was evaluated in logistic models with risk variables. Results: We analyzed 643 patients, with a median age of 93.6 months. The median length of stay was 6 days (range 2 to 192 days). There were 88 deaths (13.7%). Among the 555 survivors, 36 patients (6.5%) had a new morbidity at hospital discharge. From these, in 33 patients (5.9%), the degree of impairment was at least moderate (FSS score ≥ 10); in 7 (1.25%), was severe (FSS ≥ 16). The mean FSS at admission was 6.87 (SD: 1.9) and, at discharge, 7.23 (SD: 2.73; P = 0.017 in the T test). The variables “PRISM IV value” (odds ratio [OR] = 1.08, P = 0.001), ‘age in months’ (OR = 0.99, P = 0.004) and “central nervous system tumor” (OR = 3.57, P = 0.000) were independent predictors of new morbidity in a multivariate model.Conclusions: Functional impairments are related to the degree of physiological derangement, younger age and CNS neoplasms, and can theoretically be predicted in statistical models.