Interaction of NHE1 and TRPA1 Activity in DRG Neurons Isolated from Adult Rats and its Role in Inflammatory Nociception

Vladimir A. Martínez-Rojas,Ana B. Salinas-Abarca,Norma L. Gómez-Víquez,Vinicio Granados-Soto,Francisco Mercado,Janet Murbartián

Neuroscience（2021）

Cited 4|Views7

No score

Abstract

•Zoniporide reduced pHi and increased intracellular calcium concentration in small DRG neurons sensitive to AITC.•A-967079 prevented zoniporide-induced increased intracellular calcium in small DRG neurons.•Zoniporide reduced TRPA1 channel desensitization induced by AITC in DRG neurons.•Zoniporide increased CFA-induced mechanical hypersensitivity, and this effect is prevented by a TRPA1 blocker.•CFA up-regulated TRPA1 and down-regulated NHE1 protein expression in DRG.

Translated text

Key words

A-967079,AITC,BCECF-AM, 2′,7′-Bis-(2-Carboxyethyl)-5-(and-6)-Carboxyfluorescein,CFA,DRG,Fura-2 AM,NHE,TRPA1,Zoniporide

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined