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Stem cell models help crack regional oncohistone codes driving childhood gliomas.

Rachel H Klein,Paul S Knoepfler

Cell stem cell（2021）

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Abstract
In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.
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