Ultra-low coverage whole genome sequencing of ccfDNA in multiple myeloma: A tool for laboratory routine?

Laura Yissel Rengifo,Sanne Smits,Lieselot Buedts,Michel Delforge,Luc Dehaspe,Thomas Tousseyn,Nancy Boeckx,Stefan Lehnert,Lucienne Michaux,Joris Robert Vermeesch,Peter Vandenberghe,Barbara Dewaele

Cancer treatment and research communications（2021）

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摘要

This proof-of-principle study indicates that ULCS of ccfDNA can reveal CNAs in MM and should be explored further as a cost-efficient alternative, especially in cases where BM-PC purification fails.

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关键词

Chromothripsis,Molecular cytogenetics,Multiple myeloma,Tumor fraction,Ultra‐low coverage sequencing

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