Cross-talk between next generation sequencing methodologies to identify genomic signatures of esophageal cancer

Renu Verma,Real Sumayya Abdul Sattar, Nimisha, Apurva, Arun Kumar,Abhay Kumar Sharma, Mamta Parveen Sumi, Ejaj Ahmad,Asgar Ali, Bhawna Mahajan,Sundeep Singh Saluja

Critical Reviews in Oncology/Hematology（2021）

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Abstract

•Esophageal cancer (EC) is one of the most lethal malignancies worldwide.•More than half a million cases of EC are diagnosed each year worldwide.•Multidisciplinary approaches are used to identify diagnostic/prognostic markers.•NGS based approaches viz. WGS, WES, and RNA-Seq have revolutionized the detection of genetic changes across the genome.•NGS based advances help to the identify new targets for drug development.

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Key words

Next generation sequencing,Esophageal cancer,PI3K/AKT/mTOR,Targeted therapy

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