Preclinical Assessment Addressing Intravenous Administration Of A [Ga-68]Ga-Psma-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, Pet Imaging, And Biodistribution

It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [Ga-68]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [Ga-68]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.