Synthesis of an organic-inorganic hybrid with short organic molecular chains by sol-gel chemistry
Journal of the Mechanical Behavior of Biomedical Materials(2021)
摘要
An oligomer with short organic molecular chains was successfully synthesized with KH550 and KH560. This oligomer was combined with tetraethyl orthosilicate and calcium chloride to prepare an organic-inorganic hybrid biological material (OI-BM) by sol-gel chemistry. The hybrid was fully characterized by a series of instrumental characterizations including nuclear magnetic resonance spectrometry, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray energy spectroscopy and inductively coupled plasma spectrometry. OI-BM presented elastic deformation under compression. The elastic modulus and ultimate stress of OI-BM were 0.4 ± 0.1 GPa and 23.0 ± 4.0 MPa, respectively, lower than those of 45S5 bioactive glass (45S5-BG), whereas the strain at failure and modulus of toughness of OI-BM was about 4.5 times and 4 times higher. The hybrid is easy to form due to the improved mechanical property, suggesting excellent machining properties. The hybrid OI-BM produced hydroxyapatite in 1 h in simulated body fluid due to its excellent bioactivity. CCK-8 assay further demonstrated the desirable cytocompatibility of the hybrid. Thus, the hybrid can be a potential material for satisfying the mechanical property requirement of an implant.
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关键词
Hybrid,Biomaterials,Sol-gel,Mechanical properties,3-Methylacryoxypropyltrimethoxy silane
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