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Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance.

George E Stenhouse,Khuzwayo C Jere,Chikondi Peno,Rebecca J Bengtsson,End Chinyama,Jonathan Mandolo,Amy Cain,Miren Iturriza-Gómara,Naor Bar-Zeev,Nigel A Cunliffe,Jennifer Cornick,Kate S Baker

Microbial genomics（2021）

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Abstract
Increasing antimicrobial resistance and limited alternative treatments have led to fluoroquinolone-resistant Shigella strain inclusion on the WHO global priority pathogens list. In this study we characterized multiple Shigella isolates from Malawi with whole genome sequence analysis, identifying the acquirable fluoroquinolone resistance determinant qnrS1.
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