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Targeting the PI3K and MAPK Pathways to Improve Response to HER2-targeted Therapies in HER2-positive Gastric Cancer

Mezynski M. Janusz,Farrelly Angela M.,Cremona Mattia,Carr Aoife,Morgan Clare,Workman Julie,Armstrong Paul,McAuley Jennifer,Madden Stephen,Fay Joanna,Sheehan Katherine M.,Kay Elaine W.,Holohan Ciara,Elamin Yasir,Rafee Shereen,Morris Patrick G.,Breathnach Oscar,Grogan Liam, Beaumont Hospital,Toomey Sinead

Journal of Translational Medicine（2021）

Cited 23|Views52
Key words
HER2-positive gastric cancer,Signalling pathway activation,PI3K,MAPK,Targeted therapies,Somatic mutations,Treatment resistance
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