A stop sign for RAS trafficking
NATURE CHEMICAL BIOLOGY(2021)
摘要
N-Ras lipidation cycling is known to regulate its trafficking and function. A new S -depalmitoylation inhibitor induces N-Ras membrane mislocalization, providing insights into N-Ras function and laying the foundation for a new cancer therapeutic strategy.
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关键词
Cancer,Lipids,Membrane trafficking,Small molecules,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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