The structure of a virus-encoded nucleosome
NATURE STRUCTURAL & MOLECULAR BIOLOGY(2021)
Abstract
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form ‘forced’ heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.
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Key words
DNA,Electron microscopy,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy
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