Serotype Switch Variant Of Multidrug-Resistant Streptococcus Pneumoniae Sequence Type 271
EMERGING INFECTIOUS DISEASES(2021)
Abstract
We discovered 3 invasive, multidrug-resistant Streptococcus pneumoniae isolates of vaccine-refractory capsular serotype 3 that recently arose within the successful sequence type 271 complex through a serotype switch recombination event. Mapping genomic recombination sites within the serotype 3/sequence type 271 progeny revealed a 55.9-kb donated fragment that encompassed cps3, pbp1a, and additional virulence factors.
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Key words
ST271 lineage,Streptococcus pneumoniae,antimicrobial resistance,bacteria,capsular switch,pneumococcal,pneumococcus,recombination,respiratory infections,serotype 3,streptococci,vaccines
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