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Genetic reduction of tyramine β hydroxylase suppresses Tau toxicity in a Drosophila model of tauopathy

Varuna Nangia, Julia O'Connell, Kusha Chopra, Yaling Qing, Camille Reppert,Cynthia M Chai, Kesshni Bhasiin,Kenneth J Colodner

Neuroscience Letters（2021）

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Abstract
•Genetic reduction of tβh suppresses Tau toxicity in a Drosophila model of tauopathy.•tβh-mediated Tau suppression is independent of Tau phosphorylation.•Overexpression of tβh in the Drosophila eye does not modify Tau toxicity or phosphorylation.
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Key words
AD,FTLD-Tau,LC,PSP,tβh,dβh
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