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Transition-Metal-Free Oxidative Cyclization Reaction Of Enynals To Access Pyrane-2-One Derivatives

ORGANIC & BIOMOLECULAR CHEMISTRY(2021)

Cited 2|Views6
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Abstract
A novel and efficient metal-free C-H functionalization of enynals is developed to synthesize alpha-pyrone derivatives via the formation of two C-O bonds. In this project, K2S2O8 has been introduced as an efficient oxygen source and C-H functionalization agent in regioselective oxidative cyclization reaction with a relatively broad substrate scope.
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Key words
cyclization,enynals,transition-metal-free
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