The Enhancement of Antiviral Activity of Chloroinconazide by Aglinate-based Nanogel and Its Plant Growth Promotion Effect

Improving the efficiency and prolonging the duration of pesticides are of great significance in agricultural production. In this work, based on the antiviral compound chloroinconazide (CHI) synthesized previously, the improvement of the fabricated CHI-loaded alginate-based nanogel (CHI@ALGNP) was studied. It was found that CHI@ALGNP showed higher foliar adhesion than CHI and exhibited a sustained release for up to 7 days. CHI@ALGNP could also continuously activate the reactive oxygen species and antioxidant levels and induce the increase of salicylic acid content and the expression of its responsive gene PR2 for a long time, thus achieving sustained resistance to tobacco mosaic virus infection in Nicotiana benthamiana. Strikingly, CHI@ALGNP could release Ca2+ and Mg2+ to promote the growth of N. benthamiana. Taken together, for the first time, we have shown the improvement of a nanogel carrier to the antiviral activity and growth promotion of small molecular pesticides. As the alginate-based nanogel can be easily applied to the spray-based pesticide delivery technology, our study provides a new strategy for the development of new pesticide preparations and the application of multifunctional pesticides.