Click nucleic acid polymers and methods of use

Bowman Christopher N,Xi Weixian,Pattanayak Sankha

user-5fe1a78c4c775e6ec07359f9（2019）

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摘要

Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Huntington's Disease and the like.

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关键词

Trimer,Nucleic acid,Trinucleotide repeat expansion,Tetramer,Sense (molecular biology),Dimer,Polymer,Stereochemistry,Chemistry

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