Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press

•Transfer of ready-to-use excipients from compaction simulator to rotary tablet press is feasible.•Scale-up process of orodispersible mini-tablets following FDA/EMA guidelines succeeds.•Critically quality attributes like mass, tensile strengths and disintegration time are affected during scale-up.