TPQCI: A topology potential-based method to quantify functional influence of copy number variations

Yusong Liu,Xiufen Ye,Xiaohui Zhan,Christina Y Yu,Jie Zhang,Kun Huang

Methods（2021）

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摘要

•TPQCI is a metric to effectively quantify the influence of CNV on genes.•TPQCI can capture both gene and functional level associations.•TPQCI use topology potential to integrate both network and CNV events information.•TPQCI-based module detection can help identify driving cytogenetic aberrations.

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关键词

Gene module detection,Functional influence of CNV,Protein-protein interaction network,Copy number variation,Topology potential,Multi-omics data integration

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