Effect of Standard and High-Fat Diets during Modeling of Streptozotocin-Induced Diabetes in Rats on the Development of Complications

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE(2021)

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摘要
For evaluation of the effect of high-fat diet on the development of diabetic complications, the rats were maintained on standard or high-fat diet. In 3 weeks, diabetes mellitus was modeled by single intraperitoneal injection of streptozotocin. Changes in hematological parameters, physical and biochemical parameters of the urine, and in the development of thermal allodynia were different after 15-week standard and high-fat diets.
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关键词
diabetes mellitus,streptozotocin,high-fat diet,in vivo model,rats
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