Subiculum As A Generator Of Sharp Wave-Ripples In The Rodent Hippocampus

Sharp wave-ripples (SWRs) represent synchronous discharges of hippocampal neurons and are believed to play amajor role inmemory consolidation. A large body of evidence suggests that SWRs are exclusively generated in theCA3-CA2 network. In contrast, here, weprovide several lines of evidence showing that the subiculum can function as a secondarySWRs generator. SWRswith subicular origin propagate forward into the entorhinal cortex aswell as backward into the hippocampus proper. Our findings suggest that the output structures of the hippocampus are not only passively facilitating the transfer of SWRs to the cortex, but they also can actively contribute to the genesis of SWRs. We hypothesize that SWRs with a subicular origin may be important for the consolidation of information conveyed to the hippocampus via the temporoammonic pathway.Y