The Cgas-Sting Pathway Connects Mitochondrial Damage To Inflammation In Burn-Induced Acute Lung Injury In Rat

Activation of the cGAS-STING pathway by increased plasma mtDNA is an important pathway driving neutrophil infiltration in burn-induced acute lung injury in rats. A further understanding of the STING-mediated immunopathology in lung and other susceptible organs may be important for the development of novel therapies for burn injury.