Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. Michael J. Palmer , Xiaoyi Deng , Shawn Watts , Goran Krilov , Aleksey Gerasyuto , Sreekanth Kokkonda , Farah El Mazouni , John White , Karen L. White , Josefine Striepen , Jade Bath , Kyra A. Schindler , Tomas Yeo , David M. Shackleford , Sachel Mok , Ioanna Deni , Aloysus Lawong , Ann Huang , Gong Chen , Wen Wang , Jaya Jayaseelan , Kasiram Katneni , Rahul Patil , Jessica Saunders , Shatrughan P. Shahi , Rajesh Chittimalla , Inigo Angulo-Barturen , Maria Belen Jimenez-Diaz , Sergio Wittlin , Patrick K. Tumwebaze , Philip J. Rosenthal , Roland A. Cooper , Anna Caroline Campos Aguiar , Rafael V. C. Guido , Dhelio B. Pereira , Nimisha Mittal , Elizabeth A. Winzeler , Diana R. Tomchick , Benoit Laleu , Jeremy N. Burrows , Pradipsinh K. Rathod , David A. Fidock , Susan A. Charman , Margaret A. Phillips Journal of Medicinal Chemistry（2021）
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