Family History In Patients Who Would Have Been Candidates For Active Surveillance

Introduction: It is unknown whether a family history of prostate cancer confers additional risk among men who are candidates for active surveillance (AS).Materials and methods: Using a prospectively maintained database of men who underwent radical prostatectomy (RP) (2010-2018), candidates for AS were identified according to the expanded criteria. Pathological upgrading was defined as a pathologic Gleason score (pGS) of 3+4 or higher for patients with a biopsy GS of 3+3 and a pGS of 4+3 or higher for patients with a biopsy GS of 3+4. Major upgrading was defined as a pGS of 4+4 or higher. The chi(2) test was used for comparisons.Results: Of 1,320 men who were candidates for AS, 288 (21.8%) had a family history of prostate cancer. There were no differences in terms of the age, number of positive cores, or number of patients with a GS of 7 between the two groups. Pathological upgrading was observed in 61.1% of the total cohort, with no difference observed between the two groups (60.7% versus 62.5%; p = 0.5).Conclusion: In men who are eligible for AS according to the expanded criteria, a family history of prostate cancer does not appear to be associated with adverse pathology at RP.