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Effect of type II diabetes-induced osteoarthritis on articular cartilage aging in rats: A study in vivo and in vitro

Wang Haoran,Zhu Zihan,Wu Junnan,Wang Hongbin,Gao Li,Xiao Jianhua

Experimental Gerontology（2021）

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Abstract
•T2DM-induced OA can aggravate the aging of articular cartilage in aging individuals.•High concentration glucose can cause a certain degree of damage, degradation, and aging of chondrocytes.•High concentration of glucose could decrease the secretion of COL-II, increase the expression of MMP-13, p53, p21, and p16, and increase the production of ROS.
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Key words
Type II diabetes mellitus,Osteoarthritis,Cartilage,Aging
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