Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE(2020)
Abstract
The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.
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Key words
SARS-CoV-2,virtual screening,ACE2,romidepsin,molecular dynamics,HDAC inhibitors
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