Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2

Ke Liu, Rongfeng Zou, Wenqiang Cui, Meiqing Li, Xueying Wang, Junlin Dong, Hongchun Li, Hongpei Li, Peihui Wang, Ximing Shao, Wu Su, H. C. Stephen Chan, Hongchang Li, Shuguang Yuan

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE（2020）

Cited 25|Views11
No score
Abstract
The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.
More
Translated text
Key words
SARS-CoV-2,virtual screening,ACE2,romidepsin,molecular dynamics,HDAC inhibitors
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined