Ga-68 labeling of stable neurotensin(8-13) analogs via carbamoylated arginine residues gives NTS 1 R PET ligands with promising in vitro profile

Ziel/Aim The neurotensin receptor 1 (NTS1 R) is considered an interesting target for cancer diagnosis and therapy as it is overexpressed in various tumors (e.g. colorectal and pancreatic carcinoma). Applying the concept of functionalized carbamoylated arginines (1), we aimed at the synthesis and in vitro characterization of stable Ga-68 labeled NTS1 R PET ligands derived from neurotensin(8–13) (NT(8–13)).