Construct and method for the internalization of cargo molecules into a cell
user-5f8cf9244c775ec6fa691c99(2009)
Abstract
The present invention relates to the delivery of molecules into cells. Especially, it relates to a carrier complex comprising (i) a molecule comprising a receptor peptide and a peptide which is capable of penetrating a host cell; and (ii) a second molecule comprising a ligand peptide and a cargo molecule of interest. In a preferred embodiment, the carrier complex comprises (i) a fusion protein between the TAT-peptide of HIV I and streptactin, a streptavidin mutant; and (ii) a conjugate or a fusion protein between the Strep-tag II, a streptavidin-binding peptide, and the cargo molecule to be delivered.
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Key words
Fusion protein,Streptavidin,Peptide,Internalization,Conjugate,Receptor,Ligand,Mutant,Biophysics,Chemistry
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