AMPLITUDE: A study of niraparib in combination with abiraterone acetate plus prednisone (AAP) versus AAP for the treatment of patients with deleterious germline or somatic homologous recombination repair (HRR) gene-altered metastatic castration-sensitive prostate cancer (mCSPC).

Dana E. Rathkopf, Kim N. Chi, David Olmos, Heather H. Cheng, Neeraj Agarwal, Julie N. Graff, Shahneen Kaur Sandhu, Vinny Hayreh, Angela Lopez-Gitlitz, Peter St. John Francis, Gerhardt Attard

JOURNAL OF CLINICAL ONCOLOGY（2021）

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Abstract

TPS176Background: Clinical benefit has been observed with poly(ADP-ribose) polymerase (PARP) inhibition in patients with metastatic castration-resistant prostate cancer tumors that carry HRR gene d...

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Key words

Abiraterone acetate,Prostate cancer,Germline,Homologous recombination,Somatic cell,Prednisone,Poly ADP ribose polymerase,Cancer research,Polymerase,Medicine

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