A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could Be Present under in Vivo Conditions.
Journal of Pharmaceutical Sciences(2021)
关键词
Albumin-facilitated,Clearance,DMPK,Human,Microsomes,Hepatocytes,IVIVE,PBPK modeling,Pharmacokinetics
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