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Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorate collagen-induced arthritis via immunomodulatory T lymphocytes

Ke Xu,Dan Ma,Gailian Zhang,Jinfang Gao,Yazhen Su,Sumiao Liu,Yang Liu,Jian Han,Min Tian,Chun Wei,Liyun Zhang

Molecular Immunology（2021）

Cited 18|Views5
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Abstract
•hUCMSC-sEVs alleviated collagen-induced arthritis.•sEVs regulated T lymphocyte proliferation, apoptosis and differentiation into Th17 and Treg cells.•sEVs increased the expression of IL-10 and TGF-β , decreased IL-17 expression.
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APC,CFA,CIA,CII,Exos,sEVs,FITC,FOXP3,GADPH,HSP70,hUCMSCs,MPs,MTX,IL,PBMCs,PI,RA,RORγt,RT-PCR,TGF-β,TNF-α,Th17,Treg
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