Brain Transcriptome Responses to Dexamethasone Depending on Dose and Sex Reveal Factors Contributing to Sex-Specific Vulnerability to Stress-Induced Disorders.

Eduard Murani,Nares Trakooljul,Frieder Hadlich,Siriluck Ponsuksili,Klaus Wimmers

Neuroendocrinology（2022）

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摘要

The discovered expression signatures suggest that DEX induced a dysfunctional state of microglia in males, while in females microglia were primed, which could entail predisposition for different mental disorders.

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关键词

Glucocorticoid receptor,Hypothalamus-pituitary-adrenal axis,Mental disorder,Sex differences,Stress,Transcriptome

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