Effects of Perfusion Pressures on Podocyte Loss in the Isolated Perfused Mouse Kidney.

Thiago Strieder,Victor G Puelles,Michael Vogt,Eva M Buhl,Turgay Saritas,Ralf Hausmann,Viktor Sterzer,Katja Leuchtle,Peter Boor,Jürgen Floege,Marcus J Moeller,Eleni Stamellou

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

This work provides the first experimental evidence that podocytes are extraordinarily resistant to acutely increased perfusion pressures in an ex vivo isolated kidney perfusion model. Only in glomerular disease, significant numbers of injured podocytes detached following acute increases in perfusion pressure.

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关键词

Glomerular hypertension, Glomerular hyperfiltration, Mechanical stress, Progression, CKD, Chronic kidney disease

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