A repurposed drug screen identifies compounds that inhibit the binding of the COVID-19 spike protein to ACE2.
bioRxiv : the preprint server for biology(2021)
摘要
Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2701 compounds from a commercial library of drugs approved by international regulatory agencies for their ability to inhibit the binding of recombinant, trimeric SARS-CoV-2 spike protein to recombinant human ACE2. We identified 56 compounds that inhibited binding by <90%, measured the EC
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关键词
spike protein,ace2,repurposed drug screen
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