A Novel Metal Organic Gel With Superior Oxidase-Like Activity For Efficient And Sensitive Chemiluminescence Detection Of Uric Acid

It is found that MIL-100(Fe) gels, as a kind of metal-organic gels (MOGs), constitutting of iron (Fe3+) and trimesic acid (H3BTC), has been regarded as the efficient catalyst of luminol chemiluminescence (CL) system without the presence of extra oxidants in the present work. MIL-100(Fe) gels that have possessed mimicking oxidase-like activity can excellently enhanced luminol CL intensity by accelerating the generation of reactive oxygen species. Furthermore, with the addition of uric acid (UA), the CL signal has been dramatically inhibited under alkaline condition. Hence, the CL intensity inhibiting ratio (IA) was proportional to the increasing concentration of UA in the rang from 10 nM to 4000 nM with the detection limit of 5.9 nM. This method has been successfully applied for analysis of UA with acceptable recoveries ranging from 97.0% to 107.9% in urine sample. These results indicates that this study open up a novel, sensitive and convenient method to detect UA in biological samples. (C) 2021 Elsevier B.V. All rights reserved.