Generation of non-human primate models of Alzheimer's disease.

Hiroki Sasaguri,Kenya Sato,Wakako Kumita,Takashi Inoue,Yoko Kurotaki,Kenichi Nagata,Naomi Mihira,Kaori Sato,Tetsushi Sakuma,Takashi Yamamoto,Michihira Tagami,Riichiroh Manabe,Kokoro Ozaki,Yasushi Okazaki,Takaomi C Saido,Erika Sasaki

Alzheimers & Dementia（2021）

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摘要

To our knowledge, we have successfully generated the word's first AD model of non-human primates. These animals are expected to show early amyloid pathology in the brain and to contribute to cutting-edge research to elucidate primate-specific mechanism in AD. In addition, we will make the mutant animals available to researchers worldwide in the fight against AD in the future.

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