Relación entre los niveles de interleucina 6 y depresión en pacientes afectados por Covid-19

Introduction: Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms.Objectives: To assess correlation between IL-6, IL-1 beta and TNF-alpha and depressive symptoms. Characterize the depressive symptoms present.Methods: Observational study. Patients admitted for Covid-19 older than 60 years with a interleukin determination were included. The Yesavage Geriatric Depression Scale (GDS) was used, associating each item with a neurotransmitter.Results: 27 patients included. We did not find correlation between IL-6 levels and the GDS scale score (rho = 0.204; 95% CI -0.192 to 0.543); with IL-1 beta levels (rho = -0.126; 95% CI -0.490 to 0.276); nor of TNF alpha (rho = -0.033; 95% CI -0.416 to 0.360). 3 patients (11.1%) presented score compatible with depressive disorder. It was associated with a deficiency of noradrenaline and serotonin.Conclusions: We found no correlation between the levels of IL-6, IL-1 beta, and TNF-alpha with the GDS score. Depressive symptomatology is similar to vascular depressions.(c) 2020 Elsevier Espana, S.L.U. All rights reserved.