TNF-α Gene G308A Polymorphism: Frequency in Patients with Type 2 Diabetes Mellitus
International journal of current research and review(2020)
摘要
Over the last few years, roles of cytokines in the pathogenesis of human diseases are being studied intensively.1,2 The Tumour necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, is a highly active polyfunctional cytokine playing a key role in the pathogenesis of diseases such as Rheumatoid arthritis, Parkinson Disease, Obesity, Diabetes Mellitus (DM) and making an impact on the regulation of metabolism in a human organism.3 Under physiological conditions, TNF-α plays a critical role in the regulation of normal differentiation, growth and metabolism of various cells involved in mechanisms of cell death and apoptosis. On the other hand, TNF-α acts as a mediator of inflammation in various human diseases.1,2 Findings from multiple studies demonstrated interrelation between increase in TNF-α levels and the initiation of inflammation and cancer, as well as of some metabolic, autoimmune and neurodegenerative diseases.2,5-7 There is convincing evidence of TNF-α as a key pro-inflammatory . ABSTRACT
更多查看译文
关键词
gene g308a polymorphism,diabetes mellitus
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要