76 - Antiapoptotic Bcl-xL Preserves the Transcriptional, Morphological and Functional Integrity of β-Cell Mitochondria During Chronic Glucose Excess

Nutrient stress contributes to β-cell failure in type 2 diabetes. We previously reported that antiapoptotic Bcl-xL dampens β-cell glucose signalling. Here, we examined if Bcl-xL is important for β-cell mitochondrial homeostasis during prolonged exposure to excess glucose.