Synthesis of 3-Methylthio-benzo[b]furans/Thiophenes via Intramolecular Cyclization of 2-Alkynylanisoles/Sulfides Mediated by DMSO/DMSO-d6 and SOCl2
Chinese Journal of Chemistry(2021)
Abstract
Main observation and conclusion The reaction of 2-alkynylanisoles/sulfides with SOCl2 and DMSO was conducted to conveniently furnish the biologically interesting 3-(methylthio)-benzo[b]furans/thiophenes via intramolecular cyclization. DMSO acts as a solvent as well as a sulfur source and can also be replaced with DMSO-d(6), enabling the incorporation of the SCD3 moiety of DMSO-d(6) to the 3-position of the heterocyclic frameworks.
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Key words
3‐, Methylthio‐, benzo[b]furans, Thiophenes, 2‐, Alkynylanisoles, Sulfides, DMSO, DMSO‐, d(6), SOCl2, Interrupted pummerer process
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