A Clinical Laboratory Evaluation Of Performance Characteristics Of A Clinical Decision Support Tool For Disease Complications In Crohn'S Disease

Background Patients with Crohn's disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated. Methods CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and validated in 2 cohorts. Tool prediction of disease characteristics was assessed using Cox regression and Harrell's C-statistic. Results All associations of CD complications and CDPATH components were significant except perianal location. There was a significant association between individualized risk assessment scores and CD complications in both cohorts. Conclusion CDPATH is validated as a clinical decision support tool for assessing the risk of CD complications. Lay Summary CDPATH risk assessment tool (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was developed to assess individual risk of Crohn's disease (CD) complications. We validated this decision support tool that may aid gastroenterologists in facilitating optimal management of CD.