Metal‐Based Nanoparticles: Shedding Light on Metal‐Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution (Small 31/2020)

Superparamagnetic iron oxide nanoparticles (SPIONs) are clinically used as diagnostic agents, serving as a contrast media when exposed to a magnetic field. In article number 2000746, Jörg Huwyler and co-workers evaluate synchrotron radiation-based hard X-ray tomography (SRμCT) for the localization of SPIONs in soft tissues. In the cover, the tissue distribution of SPIONs is visualized after intravenous injection in a three-day old zebrafish embryo by SRμCT, with views within the blood vessel looking at the surrounding soft tissue and onto SPIONs engulfed by macrophages. Image: Courtesy of Jan Stephan Bolten.