Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

Iron Catalyzed [3+2] Cycloaddition of Tetrahydroisoquinoline: Synthesis of Dihydropyrrolo[2,1-a]isoquinolines

Si-Wei Liu,Dan-Dan Ma,Xin-Xin Zhu, Cheng-Dan Luo,Hui-Lin Tan,Xiao-Li Ju,Xue Tan,Xiao-Hui Tang,Jie Huang, Jia Wang,Xian-Xun Wang,Hai-Lei Cui

ASIAN JOURNAL OF ORGANIC CHEMISTRY（2020）

Cited 9|Views1
No score
Abstract
We have developed an iron(III) chloride hexahydrate catalyzed formal [3+2] cycloaddition of tetrahydroisoquinolines with amide group-bearing Morita-Baylis-Hillman (MBH) carbonates. A range of highly functionalized dihydropyrrolo[2,1-a]isoquinolines could be prepared through SN2'/oxidation/electrocyclization/aromatization cascade (32-62% yield).
More
Translated text
Key words
Iron chloride,Dihydropyrrolo[2,1-a]isoquinoline,Tetrahydroisoquinoline,Cycloaddition,Morita-Baylis-Hillman carbonate
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined