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The Next-Generation Ret Inhibitor Tpx-0046 Is Active In Drug-Resistant And Naive Ret-Driven Cancer Models.

Alexander E. Drilon,Dayong Zhai,Evan Rogers,Wei Deng, Xin Zhang,Jane Ung,Dong Lee,Laura Rodon,Armin Graber,Zachary Franklin Zimmerman,Brion W Murray,Vivek Subbiah

JOURNAL OF CLINICAL ONCOLOGY（2020）

Cited 30|Views13
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Abstract
3616Background: RET fusions/mutations drive oncogenesis in lung and thyroid cancers, and several other malignancies. Selective RET inhibitors (selpercatinib/pralsetinib) are active in patients with...
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cancer models,inhibitor,next-generation,drug-resistant,ret-driven
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