A Phase I Study Of Mrna-2752, A Lipid Nanoparticle Encapsulating Mrnas Encoding Human Ox40l, Il-23, And Il-36 Gamma, For Intratumoral (Itu) Injection Alone And In Combination With Durvalumab.

Manish R. Patel,Todd Michael Bauer,Antonio Jimeno,Ding Wang,Patricia LoRusso,Khanh Tu Do,Salomon M. Stemmer,Corinne Maurice-Dror,Ravit Geva,Sima Zacharek,Andressa S Laino,Jing Sun,Joshua Frederick,Honghong Zhou,William Randolph, Pamela Sarah Cohen,Robert S. Meehan,Ryan J. Sullivan

JOURNAL OF CLINICAL ONCOLOGY（2020）

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摘要

3092Background: mRNA-2752 is a novel mRNA-based therapeutic agent encoding OX40L T cell co-stimulator, IL-23 and IL-36γ pro-inflammatory cytokines. Here we present findings from a first-in-human st...

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lipid nanoparticle,mrnas,injection

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